Table 1.
Mouse TLRs, their principal ligands, and the adaptors that serve them
| TLR | Associated proteins | Ligands | Adaptors |
|---|---|---|---|
| TLR1/2 | CD14, CD36, Dectin1 | Ac3LP, Glycolipids | MyD88,Tirap |
| TLR2/6 | CD14, Dectin1 | Ac2LP, LTA, Zymosan | MyD88, Tirap |
| TLR3 | polyI:C, dsRNA | TRIF | |
| TLR4 | CD14, MD-2 | LPS, Taxol, Heparan, Hyaluronate, F-prot, RSV, G-prot, VSV, Env prot, MMTV, others | MyD88,Tirap TRIF,TRAM |
| TLR5 | Flagellin | MyD88 | |
| TLR7 | ssRNA, imiquimod, loxoribine, other | MyD88 | |
| TLR9 | ? Effete | CpG, DNA | MyD88 |
| TLR11 | Profilin | MyD88 | |
| TLR12 | ? | ? | |
| TLR13 | ? | ? |
Associated proteins indicate cell-surface molecules that are known to have essential accessory roles for the detection of at least some ligands based on the effects of ENU-induced mutations or gene targeting.