Fig. 2.
Stunted growth and perinatal lethality of Ppp1r15b−/− mice. (A) Graph depicting the distribution of genotypes found in 10-day-old pups born of Ppp1r15b+/− parents. (*Probability of finding no Ppp1r15b−/− progeny among 99 individuals by chance; P = 2.5 × 10−60.) (B) Graph depicting the mean weights + SD of e18.5 embryos conceived by Ppp1r15+/− parents. Paired two-tailed t-test results with P values are indicted above brackets. (C) Photograph of newborn Ppp1r15b+/+, Ppp1r15b+/−, and Ppp1r15b−/− mice. (D) Immunoblot of eIF2(αP), total eIF2α, and GADD34 from cytoplasmic extracts prepared from the liver of newborn mice of the indicated genotype.