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. 2009 Feb 10;106(6):1989–1994. doi: 10.1073/pnas.0804428106

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© 2009 by The National Academy of Sciences of the USA

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Fig. 1. — Macrocephaly in Pten^+/−; Slc6a4^+/− mice. (A) Representative dorsal-view images of brains from male Pten^+/+; Slc6a4^+/+, Pten^+/−; Slc6a4^+/+, Pten^+/+; Slc6a4^+/−, and Pten^+/−; Slc6a4^+/− mice. Brains were collected at 12 weeks of age. (B and C) As compared to wild-type controls, Pten and Slc6a4 haploinsufficient mice show a significant increase in brain mass. (B) Brain mass in females is significantly increased in Pten^+/−; Slc6a4^+/− mice as compared to Pten^+/+; Slc6a4^+/+, Pten^+/−; Slc6a4^+/+, and Pten^+/+; Slc6a4^+/− mice (F_3,42 = 20.6; P < 0.001). n = 10 Pten^+/+; Slc6a4^+/+, 10 Pten^+/−; Slc6a4^+/+, 10 Pten^+/+; Slc6a4^+/−, and 13 Pten^+/−; Slc6a4^+/− mice. (C) Brain mass in males is significantly increased in Pten^+/−; Slc6a4^+/− mice compared to Pten^+/+; Slc6a4^+/+, Pten^+/−; Slc6a4^+/+, and Pten^+/+; Slc6a4^+/− mice (F_3,33 = 30.0; P < 0.001). n = 6 Pten^+/+; Slc6a4^+/+, 6 Pten^+/−; Slc6a4^+/+, 11 Pten^+/+; Slc6a4^+/−, and 11 Pten^+/−; Slc6a4^+/− mice.*, P < 0.05; **, P < 0.01 [Tukey's honestly significant difference (HSD) test]. Ages were 8–12 weeks. Data are normalized to body mass to account for differences in body mass between animals.