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. 2009 Feb 10;106(6):1989–1994. doi: 10.1073/pnas.0804428106

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© 2009 by The National Academy of Sciences of the USA

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Fig. 3. — Social behavior and prepulse inhibition in Pten and Slc6a4 haploinsufficient mice. (A) Social approach data for 8-week-old female Pten^+/+; Slc6a4^+/+ (n = 13), Pten^+/−; Slc6a4^+/+ (n = 13), Pten^+/+; Slc6a4^+/− (n = 11), and Pten^+/−; Slc6a4^+/− (n = 13) mice. *, P < 0.05, ANOVA within-group comparison between chamber 1 and chamber 3. Error bars indicate SEM. (B) Social approach data from A presented as approach–avoidance score for analysis across genotypes. Time spent with a social stimulus mouse in chamber 1 is significantly decreased in Pten^+/−; Slc6a4^+/− mice as compared to Pten^+/+; Slc6a4^+/+, Pten^+/−; Slc6a4^+/+, and Pten^+/+; Slc6a4^+/− mice (F_3,49 = 25.3; P < 0.001). *, P < 0.05; **, P < 0.01 (Tukey's HSD test). (C) Social approach and recognition data for 8-week-old male mice. During trial 1, the stimulus (located in chamber 1) and the subject mouse interacted for 10 min. Mice were then separated for 30 min. Trial 2 then took place, during which the subject and the stimulus mouse interacted for 5 min. Pten^+/+; Slc6a4^+/+ (n = 12), Pten^+/−; Slc6a4^+/+ (n = 10), Pten^+/+; Slc6a4^+/− (n = 8), and Pten^+/−; Slc6a4^+/− (n = 8) mice are shown. *, P < 0.05, ANOVA within-group comparison between chamber 1 and chamber 3. Error bars indicate SEM. (D) Prepulse inhibition of the acoustic startle response in 8-week-old Pten^+/−; Slc6a4^+/− mice. Pten^+/−; Slc6a4^+/+ and Pten^+/−; Slc6a4^+/− mice have significant deficits in startle inhibition at a prepulse 16 db above background (F_3,46 = 3.6; P < 0.05). *, P < 0.05 (Tukey's HSD test). n = 11 Pten^+/+; Slc6a4^+/+ (8 female), 10 Pten^+/−; Slc6a4^+/+ (7 female), 13 Pten^+/+; Slc6a4^+/− (7 female), and 13 Pten^+/−; Slc6a4^+/− (9 female) mice.