Fig. 2.

Regions of GM atrophy in all bvFTD patients compared with controls are shown in cyan. GM regions more atrophied in bvFTD patients carrying apoE ε4 relative to both bvFTD noncarriers and controls are superimposed in blue. Overlapping regions are shown in light blue. BvFTD ε4 carriers had more GM atrophy than bvFTD noncarriers in the bilateral medial, dorsolateral, orbital frontal cortex, anterior insula, and cingulate cortex with right predominance. Results are shown on the 3D rendering and axial sections of the Montreal Neurological Institute standard brain in neurological convention and displayed at the threshold specified in Materials and Methods.