TABLE 1.
IDENTIFICATION OF MOLECULAR PATHWAYS ALTERED IN NICKEL-INDUCED ACUTE LUNG INJURY OF GENE-TARGETED MICE LACKING METALLOTHIONEIN 1 AND 2 [Mt1/2(−/−)] AND 129S1/SVIMJ STRAIN-MATCHED WILD-TYPE MICE [Mt1/2(+/+)] EXPOSED TO NICKEL FOR 3 h
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Mt1/2(+/+)
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Mt1/2(+/+)
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|---|---|---|---|---|---|---|---|---|
| Pathway/GO Name | Genes Changed | Genes Measured | z Score | Pathway/GO Name | Genes Changed | Genes Measured | z Score | |
| Regulation of cell growth | 11 | 21 | 4.1 | Interleukin receptor activity | 5 | 16 | 2.6 | |
| Insulin-like growth factor binding | 8 | 13 | 3.9 | Regulation of cell growth | 5 | 21 | 2.2 | |
| Growth factor binding | 7 | 11 | 3.9 | |||||
| Extracellular matrix structural constituent conferring tensile strength | 8 | 15 | 3.4 | |||||
| Nuclear pore | 7 | 13 | 3.2 | |||||
| Collagen | 8 | 17 | 3.0 | |||||
| Cytosolic ribosome | 11 | 26 | 2.8 | |||||
| Synaptosome | 5 | 10 | 2.5 | |||||
| Ribosome | 28 | 89 | 2.4 | |||||
| Protein transporter activity | 34 | 125 | 2.4 | |||||
| Transcription from Pol II promoter | 7 | 16 | 2.3 | |||||
| Lymph gland development | 5 | 11 | 2.3 | |||||
| Ubiquitin ligase complex | 5 | 8 | 2.3 | |||||
| Peroxisome | 12 | 36 | 2.2 | |||||
| DNA packaging | 6 | 10 | 2.2 | |||||
| Cytosol | 21 | 89 | 2.1 | |||||
| Chromatin | 8 | 22 | 2.1 | |||||
| Ribosome biogenesis | 14 | 38 | 2.1 | |||||
| Structural molecule activity | 21 | 90 | 2.0 | |||||
| Neuropeptide Y receptor activity | 7 | 19 | 2.0 | |||||
Definition of abbreviations: GO, Gene Ontology Consortium; Mt, metallothionein.
MAPPFinder was used to calculate the cumulative total of genes changed for a parent GO term and its children, and provides a statistical z Score to assess significance. z Score values ⩾ 2.0 were considered to be significant.