TABLE 1.
CHARACTERISTICS OF RATS USED FOR PHARMACOKINETIC STUDIES
| Characteristics of Rats Used for 54Mn Pharmacokinetic Study
| ||||||
|---|---|---|---|---|---|---|
| Control (n) | Bled (n) | Iron Oxide Aerosol (n) | ||||
| Body weight, g | 356.40 ± 23.63 (10) | 308.20 ± 12.49 (10) | 331.30 ± 17.08 (10) | |||
| Hematocrit, % | 51.87 ± 2.28 (6) | 44.02 ± 2.22* (6) | 49.50 ± 1.31 (6) | |||
| Nonheme Fe, μg/g | ||||||
| Lungs | 15.84 ± 4.10 (5) | 12.62 ± 3.25 (4) | 1,132.34 ± 160.14* (6) | |||
| Liver | 80.09 ± 10.86 (5) | 43.31 ± 6.65* (4) | 90.66 ± 14.36 (6) | |||
| Brain | 13.84 ± 3.22 (5) | 12.64 ± 0.62 (4) | 13.08 ± 1.20 (6) | |||
| Characteristics of Rats Used for 59Fe Pharmacokinetic Study
|
||||||
| Control (n) | Bled (n) | Iron Oxide–Instilled (n) | ||||
| Body weight, g | 388.46 ± 15.85 (5) | 364.28 ± 14.33 (5) | 389.92 ± 9.02 (5) | |||
| Hematocrit, % | 45.01 ± 2.26 (5) | 34.30 ± 0.28* (5) | 46.09 ± 0.82 (5) | |||
| Non-heme Fe, μg/g | ||||||
| Lungs | 29.58 ± 4.28 (3) | 20.43 ± 2.34 (3) | 1,948.63 ± 327.77* (4) | |||
| Liver | 79.70 ± 4.62 (5) | ND | 127.22 ± 36.47 (5) | |||
| Brain | 13.80 ± 3.14 (5) | ND | 12.80 ± 1.53 (5) | |||
Data are means ± SEM. ND, not determined.
*
P < 0.05, compared with control.