TABLE 3.

DISTRIBUTION OF ⁵⁴Mn IN TISSUES 4 h AFTER INTRATRACHEAL INSTILLATION OF ⁵⁴MnCl₂ IN RATS EXPOSED TO IRON OXIDE AEROSOL AND IN REPEATEDLY BLED RATS

	4 h after Instillation
	Control	Bled	Iron Oxide Aerosol
Lungs	57.366 ± 3.623	58.068 ± 2.218	73.765 ± 2.402†
Blood	0.089 ± 0.023	0.159 ± 0.036	0.062 ± 0.019
Liver	4.965 ± 1.495	4.547 ± 2.106	2.255 ± 0.826
Heart	0.415 ± 0.039	0.471 ± 0.023	0.189 ± 0.012†
Brain	0.054 ± 0.008	0.078 ± 0.005*	0.030 ± 0.001†
Spleen	0.232 ± 0.031	0.291 ± 0.044	0.114 ± 0.005†
Kidneys	3.120 ± 0.256	3.261 ± 0.269	1.372 ± 0.089†
Stomach	0.629 ± 0.177	0.835 ± 0.232	1.081 ± 0.605
Small Intestine	6.519 ± 1.168	5.569 ± 1.386	4.233 ± 1.203
Large Intestine	2.505 ± 0.552	3.530 ± 0.815	1.578 ± 0.626
Urine	0.019 ± 0.008	0.009 ± 0.005	0.001 ± 0.000
Feces	0.002 ± 0.002	0.008 ± 0.006	0.028 ± 0.013

Values represent radioactivity (% of total instilled dose).

Each value is the mean ± SEM of five rats (multivariate ANOVA).

^*P < 0.05 control versus bled.

^†P < 0.05 control versus iron oxide aerosol.