TABLE 4.

DISTRIBUTION OF ⁵⁴Mn IN TISSUES 72 h AFTER INTRATRACHEAL INSTILLATION OF ⁵⁴MnCl₂ IN RATS EXPOSED TO IRON OXIDE AEROSOL AND IN REPEATEDLY BLED RATS

	72 h after Instillation
	Control	Bled	Iron Oxide Aerosol
Lungs	20.015 ± 1.901*	25.032 ± 1.813*	35.991 ± 2.716*†
Blood	0.118 ± 0.026	0.118 ± 0.024	0.083 ± 0.019
Liver	7.753 ± 1.529	6.884 ± 0.845	7.216 ± 0.574*
Heart	0.209 ± 0.008*	0.209 ± 0.004*	0.170 ± 0.018
Brain	0.121 ± 0.024*	0.167 ± 0.006*	0.167 ± 0.041*
Spleen	0.164 ± 0.030	0.189 ± 0.025	0.183 ± 0.007*
Kidneys	2.989 ± 0.587	3.300 ± 0.253	2.701 ± 0.082*
Stomach	0.501 ± 0.119	0.535 ± 0.111	0.457 ± 0.088
Small Intestine	2.124 ± 0.529	2.378 ± 0.327	2.601 ± 1.128
Large Intestine	5.111 ± 0.712*	4.976 ± 0.978	2.937 ± 0.327
Urine	0.029 ± 0.008	0.033 ± 0.017	0.026 ± 0.006*
Feces	24.945 ± 7.775	22.119 ± 4.162*	20.717 ± 2.778*

Values represent radioactivity (% of total instilled dose).

Each value is the mean ± SEM of five rats (multivariate ANOVA).

^*P < 0.05, 72 h versus 4 h.

^†P < 0.05 control versus iron oxide aerosol.