TABLE 5.

DISTRIBUTION OF ⁵⁹Fe IN TISSUES 4 h AFTER INTRATRACHEAL INSTILLATION OF ⁵⁹Fe IN REPEATEDLY BLED RATS OR RATS INSTILLED WITH IRON OXIDE PARTICLE SUSPENSION

	4 h after Instillation
	Control	Bled	Iron Oxide–Instilled
Lungs	48.43 ± 2.056	64.749 ± 4.134*	54.763 ± 0.594†
Blood	5.913 ± 0.597	10.843 ± 1.025*	3.650 ± 0.296†
Liver	2.944 ± 0.451	1.781 ± 0.160*	1.411 ± 0.139†
Heart	0.116 ± 0.039	0.072 ± 0.009	0.057 ± 0.008
Brain	0.053 ± 0.025	0.008 ± 0.006	0.012 ± 0.001
Spleen	0.398 ± 0.078	1.423 ± 0.330*	0.187 ± 0.033†
Kidneys	1.852 ± 1.488	0.166 ± 0.026	0.217 ± 0.023
Stomach	0.418 ± 0.082	0.877 ± 0.417	0.092 ± 0.013†
Small Intestine	1.743 ± 0.364	0.926 ± 0.132	0.809 ± 0.178†
Large Intestine	0.144 ± 0.037	0.479 ± 0.259	0.100 ± 0.022
Urine	0.022 ± 0.003	0.018 ± 0.008	0.321 ± 0.148
Feces	0.002 ± 0.001	0.006 ± 0.006	0.001 ± 0.001
Total	76.099 ± 8.075	85.807 ± 1.329	64.988 ± 0.254

Values represent radioactivity (% of total instilled dose).

Each value is the mean ± SEM of five rats (multivariate ANOVA).

^*P < 0.05 control versus bled.

^†P < 0.05 control versus iron oxide aerosol.