. 2005 Dec 15;34(4):443–452. doi: 10.1165/rcmb.2005-0352OC

TABLE 2.

ASBESTOS-INDUCED P53 PROMOTER ACTIVITY IS ABOLISHED BY AN IRON CHELATOR (PHYTIC ACID AND DEFEROXAMINE) OR FREE RADICAL SCAVENGER (SODIUM BENZOATE)

	Exposure
Condition	1 h	4 h	24 h
Control	100 ± 0^*	100 ± 0	100 ± 0
Asbestos (25 μg/cm²)	160 ± 10^†	172 ± 6^†	190 ± 5^†
+ Phytic acid (500 μM)	120 ± 8^‡	100 ± 1^‡	125 ± 5^‡
+ Deferoxamine (1 mM)	105 ± 2^‡	100 ± 1^‡	105 ± 1^‡
+ Na-benzoate (100 μM)	135 ± 22	100 ± 1^‡	109 ± 4^‡

Data expressed as mean ± SEM % control Luciferase RLU after various exposure periods (1, 4, and 24 h); n = 6.

^†

P < 0.05 versus control.

^‡

P < 0.05 versus asbestos.