Figure 1.

Genomic organization of MYLK and position of selected common SNPs on chromosome 3 with minor allele frequencies and pairwise linkage disequilibrium from European American control subjects. A shows the MYLK gene structure based on the representative mRNA sequence (GenBank Accession no. U48959) on chromosome 3 (hg16; UCSC Genome Browser on Human July 2003 Assembly). Exons are represented by blue boxes connected by gray bars representing introns, and the black bars at both sides indicate 5′ and 3′ flanking regions (5′ to 3′ direction). The horizontal dashed lines below the gene structure represented the MAF cutoff lines of 25%, 50%, and 75%, respectively. Positions and MAFs of the 17 common SNPs analyzed are represented by vertical lines below the gene structure with green color stands for MAF in EAs and the pink color for AAs measured from the bottom edge of the gray bar. B shows the LD between 17 common SNPs in EAs (estimated from 170 chromosomes) and AAs (estimated from 120 chromosomes), respectively. The strength of LD between respective pairs of SNPs is depicted by progression of color: for all D′ with LOD of > 2, the color moves from red to light blue as D′ runs from 1 (represent perfect LD) to 0; for D′ with LOD of < 2, it is represented by white.