TABLE 3.

HAPLOTYPE FREQUENCY ESTIMATES AND SIGNIFICANCE LEVELS OF CASE-CONTROL AND ALI VERSUS SEPSIS COMPARISONS FROM PERMUTATION TESTS IN 276 EUROPEAN AMERICAN SUBJECTS

Definition of abbreviations: ALI, acute lung injury; MYLK, myosin light chain kinase.

(A) Haplotype frequency estimates and significance levels of ALI or sepsis versus control comparisons. Estimated haplotype frequencies are derived from the three-locus estimated haplotype frequency analyses for the three-SNP window across a 7.2-kb region and two-locus estimated haplotype frequency analyses for the two-SNP window across a 2.4kb region in the chromosome 3 MYLK gene region. (B) Haplotype frequency estimates and significance levels of the ALI versus sepsis comparison. Two estimated haplotype frequencies are derived from the three-locus estimated haplotype frequency analyses for three-SNP window across 0.846 kb at the 5′ end of the MYLK gene.

^* P values based on 10,000 permutations.

^† P(g) is referred as global P value which derived from “omnibus” likelihood ratio test for assessing the overall haplotype frequency profile differences between the cases and control subjects.