Figure 1.

Functional analysis of significantly expressed genes. Significant genes determined by significance analysis of microarrays (SAM) analysis were annotated with gene ontology (GO) terms for cellular component, biological process, and molecular function, and overrepresented GO categories were determined using Expression Analysis Systematic Explorer software. Here, overrepresented categories among upregulated genes are shown in red and for downregulated genes in green for each of the four mouse strains analyzed in this study; black indicates that a particular category was not found to be significant. GO terms are shown to the right and corresponding GO Slim categories are presented on the left. Phenotypic classifications previously reported for each strain are outlined in Table 1 for eosinophilic airway inflammation (EOS) and airway hyperresponsiveness (AHR). Proposed associations of differential expressions to phenotypes are indicated for each GO category with blue and yellow boxes for eosinophilic infiltration and airway hyperreactivity, respectively.