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. 2006 Feb 10;34(6):711–718. doi: 10.1165/rcmb.2005-0314OC

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Figure 5. — Effect of CCR5 expression on the response to OVA treatment. (A)The airway responsiveness to methacholine (MCh), defined by the time-integrated change in peak airway pressure, or airway pressure time index (APTI), was measured. OVA treatment caused a significant increase in APTI (relative to alum-treated controls, respectively) for CCR5^+/+ mice (open bars), but not CCR5^−/− mice (stipled bars) at low-dose MCh (25 and 50 ug/kg). OVA treatment enhanced the response to 100 μg/kg MCh similarly in CCR5^+/+ (open bars) and CCR5^−/− mice (stipled bars) when compared with their respective alum-treated controls. Data are mean ± SEM; CCR5^+/+ n = 9; CCR5^−/− n = 9 mice per group. *P < 0.05. (B) The number of eosinophils in the lavage fluid in CCR5^+/+ and CCR5^−/− mice. Data are mean ± SEM; CCR5^+/+ n = 9; CCR5^−/− n = 9 mice per group. A P value of < 0.05 was considered statistically significant. *Represents statistically significant effect of OVA treatment relative to respective alum-treated genotype control.

Figure 5. — Effect of CCR5 expression on the response to OVA treatment. (A)The airway responsiveness to methacholine (MCh), defined by the time-integrated change in peak airway pressure, or airway pressure time index (APTI), was measured. OVA treatment caused a significant increase in APTI (relative to alum-treated controls, respectively) for CCR5^+/+ mice (open bars), but not CCR5^−/− mice (stipled bars) at low-dose MCh (25 and 50 ug/kg). OVA treatment enhanced the response to 100 μg/kg MCh similarly in CCR5^+/+ (open bars) and CCR5^−/− mice (stipled bars) when compared with their respective alum-treated controls. Data are mean ± SEM; CCR5^+/+ n = 9; CCR5^−/− n = 9 mice per group. *P < 0.05. (B) The number of eosinophils in the lavage fluid in CCR5^+/+ and CCR5^−/− mice. Data are mean ± SEM; CCR5^+/+ n = 9; CCR5^−/− n = 9 mice per group. A P value of < 0.05 was considered statistically significant. *Represents statistically significant effect of OVA treatment relative to respective alum-treated genotype control.