TABLE 1.
INDUCED GENES CATEGORIZED BY MOLECULAR FUNCTION
| Category | Type II cells | Genome |
|---|---|---|
| Signal | 28.4 | 21.1 |
| Phosphorylation | 12.4 | 10.6 |
| Hydrolase | 11.7 | 8.7 |
| DNA binding | 5.0 | 9.1 |
| Transferase | 10.7 | 8.2 |
| Oxidoreductase | 6.7 | 3.8 |
| ATP-binding | 8.0 | 7.3 |
| Transcription regulate | 6.7 | 10.4 |
| Receptor | 8.0 | 4.7 |
| Metal-binding | 9.4 | 6.2 |
| Transport | 9.4 | 5.9 |
| Acetylation | 3.0 | 2.1 |
| Calmodulin-binding | 0.7 | 1.0 |
| Extracellular matrix | 3.0 | 1.4 |
| Ion transport | 3.3 | 1.9 |
| Ionic channel | 3.3 | 0.2 |
| Calcium-binding | 2.0 | 3.1 |
| Cell adhesion | 3.3 | 0.4 |
| Kinase | 4.3 | 1.1 |
| Developmental | 2.0 | 2.8 |
| Serine protease | 2.3 | 1.1 |
| Isomerase | 1.3 | 0.7 |
| Lyase | 1.3 | 0.9 |
| Surface film | 1.0 | 0.03 |
For type II cells, functional category assignment was made for 299 induced genes that had data available in the Swiss-Prot and TrEMBL databases, and percent for each category was calculated (2–84 genes/category). Data for the genome represent the same calculation for all human proteins in the databases (10,125 entries). The percentages of induced type II cell genes in each functional category is similar to those for the human genome, except for the categories of ionic channel, cell adhesion, and surface film (shown in bold).