Table 5.

Summary of previous studies

Anion Gap Studies
Study	N	Sensitivity	Specificity	ROC
Iberti et al[8]	56	21%	Not Reported	Not Reported
Levraut et al[10]	498	44%	91%	0.79
Moviat et al[18]	50	45%	16%	Not Reported
Dinh et al[19]	356	39%	89%	0.76
Chawla et al[15]	285	15%	94%	0.55
Anion Gap Corrected for Albumin Studies
Study	N	Sensitivity	Specificity	ROC
Moviat et al[18]	50	100%	11%	Not Reported
Dinh et al[19]	356	75%	59%	0.75
Chawla et al[15]	285	32%	80%	0.57
Base Deficit Studies
Study	N	Results
Mikulaschek et al[11]	52	No correlation between lactate and base deficit
Waters et al [11,24]	12	Base deficit not useful, instead misleading
Chawla et al[15]	285	Base Deficit not useful, ROC AUC = 0.64

ROC = Receiver operator characteristics area under the curve, AG = anion gap, ACAG = anion gap corrected for albumin, BD = Base Deficit, sensitivity and specificity for AG and ACAG are reported at threshold of 12