Table 4.
Mean concentrations of baseline serum α-tocopherol (mg/L) according to TTPA and SEC14L2 genotypes in controls, The ATBC Study
| Genotype | Controls (n=847†) | Unadjusted |
Multivariate* |
||
|---|---|---|---|---|---|
| Mean‡ (95% CI) | % Difference§ (p-value) | Mean‡ (95% CI) | % Difference§ (p-value) | ||
| TTPA | |||||
| −980T>A | |||||
| AA | 294 | 12.0 (11.7−12.4) | Referent | 13.0 (12.7−13.4) | Referent |
| AT | 373 | 11.9 (11.6−12.2) | −0.8 (0.72) | 12.8 (12.5−13.2) | −1.5 (0.27) |
| TT | 153 | 12.0 (11.5−12.5) | 0 (0.99) | 12.6 (12.2−13.0) | −3.1 (0.03) |
| IVS1−5411G>T | |||||
| CC | 739 | 12.0 (11.8−12.2) | Referent | 12.8 (12.5−13.1) | Referent |
| AC | 56 | 12.2 (11.4−13.0) | 1.7 (0.66) | 13.1 (12.5−13.7) | 2.3 (0.28) |
| AA | 3 | 10.8 (7.3−14.3) | −10 (0.50) | 12.0 (9.7−14.3) | −6.3 (0.48) |
| IVS2−2372T>C | |||||
| CC | 508 | 11.9 (11.7−12.2) | Referent | 12.8 (12.5−13.1) | Referent |
| CT | 273 | 12.0 (11.6−12.4) | 0.8 (0.72) | 12.9 (12.5−13.2) | 0.8 (0.64) |
| TT | 40 | 11.8 (10.9−12.8) | −0.8 (0.87) | 12.8 (12.1−13.5) | 0 (0.99) |
| IVS2−2191A>G | |||||
| TT | 648 | 11.9 (11.7−12.2) | Referent | 12.8 (12.5−13.1) | Referent |
| CT | 136 | 12.0 (11.5−12.6) | 0.8 (0.72) | 12.9 (12.5−13.4) | 0.8 (0.60) |
| CC |
19 |
13.1 (11.7−14.5) |
10.1 (0.10) | 13.3 (12.4−14.3) |
3.9 (0.28) |
| SEC14L2 | |||||
| EX1−23G>A R11K | |||||
| GG | 287 | 11.7 (11.4−12.1) | Referent | 12.6 (12.2−12.9) | Referent |
| AG | 401 | 12.1 (11.8−12.4) | 3.4 (0.06) | 12.9 (12.6−13.3) | 2.4 (0.02) |
| AA | 129 | 11.9 (11.3−12.4) | 1.7 (0.64) | 13.1 (12.7−13.6) | 4.0 (0.01) |
| IVS1+111G>A | |||||
| GG | 353 | 11.9 (11.6−12.2) | Referent | 12.6 (12.3−13.0) | Referent |
| AG | 355 | 12.0 (11.7−12.3) | 0.8 (0.61) | 12.9 (12.6−13.3) | 2.4 (0.06) |
| AA | 99 | 12.1 (11.5−12.7) | 1.7 (0.51) | 13.2 (12.7−13.7) | 4.8 (0.01) |
| IVS2+182A>G | |||||
| GG | 551 | 12.1 (11.8−12.3) | Referent | 13.1 (12.7−13.4) | Referent |
| AG | 248 | 11.8 (11.4−12.2) | −2.5 (0.23) | 12.5 (12.2−12.9) | −4.6 (0.002) |
| AA | 23 | 11.9 (10.7−13.2) | −1.7 (0.85) | 12.4 (11.5−13.2) | −5.3 (0.12) |
| IVS11+931A>G | |||||
| AA | 590 | 12.0 (11.7−12.2) | Referent | 12.8 (12.5−13.2) | Referent |
| AG | 203 | 12.0 (11.6−12.4) | 0 (0.99) | 12.8 (12.5−13.2) | 0 (0.99) |
| GG | 19 | 11.5 (10.1−12.9) | −4.2 (0.54) | 12.2 (11.1−13.1) | −4.7 (0.15) |
| IVS11+1032C>T | |||||
| CC | 615 | 11.9 (11.7−12.1) | Referent | 12.8 (12.5−13.1) | Referent |
| CT | 182 | 12.1 (11.7−12.6) | 1.7 (0.39) | 12.9 (12.5−13.3) | 0.8 (0.39) |
| TT | 16 | 13.3 (11.8−14.7) | 11.8 (0.07) | 14.0 (12.9−15.0) | 9.4 (0.02) |
| IVS11+1164−>G | |||||
| GG | 444 | 12.0 (11.7−12.3) | Referent | 12.9 (12.5−13.2) | Referent |
| G/del | 304 | 11.9 (11.6−12.3) | −0.8 (0.58) | 12.8 (12.5−13.1) | −0.8 (0.68) |
| del/del | 64 | 11.9 (11.1−12.6) | −0.8 (0.70) | 12.9 (12.3−13.5) | 0 (0.90) |
| IVS11−896A>T | |||||
| TT | 278 | 12.0 (11.6−12.3) | Referent | 12.8 (12.4−13.1) | Referent |
| AT | 403 | 11.9 (11.6−12.2) | −0.8 (0.82) | 12.9 (12.6−13.2) | 0.8 (0.47) |
| AA | 139 | 11.9 (11.4−12.4) | −0.8 (0.91) | 12.7 (12.3−13.1) | −0.8 (0.72) |
| EX12−201T>C | |||||
| TT | 341 | 11.8 (11.5−12.2) | Referent | 12.6 (12.3−13.0) | Referent |
| CT | 365 | 12.0 (11.7−12.3) | 1.7 (0.40) | 13.0 (12.6−13.3) | 3.2 (0.05) |
| CC | 109 | 12.1 (11.5−12.6) | 2.5 (0.54) | 13.3 (12.8−13.7) | 5.6 (0.008) |
| EX12−71G>A | |||||
| GG | 447 | 11.9 (11.6−12.2) | Referent | 12.7 (12.4−13.1) | Referent |
| AG | 314 | 12.0 (11.7−12.4) | 0.8 (0.55) | 13.0 (12.6−13.3) | 2.4 (0.13) |
| AA | 53 | 12.4 (11.6−13.2) | 4.2 (0.23) | 13.5 (12.9−14.1) | 6.3 (0.02) |
*
Adjusted for age, body mass index, serum cholesterol concentrations, serum β-carotene concentrations, education, prior vitamin E supplement use, and daily dietary intakes of α-tocopherol, fruit, vegetables, and energy.
†
4 out of 851 controls were identified as outliers and excluded from these analyses
‡
From generalized linear models
§
Percent difference calculated as 100 × [(mean serum α-tocopherol concentration for heterozygote or recessive homozygote - mean serum α-tocopherol concentration for wild-type homozygote) / (mean serum α-tocopherol concentration for wild-type homozygote)]