Table 5.
Mean change in serum α-tocopherol concentrations (mg/L) from baseline to three years after randomization according to TTPA and SEC14L2 genotypes among controls randomized to the α-tocopherol intervention arm, the ATBC Study
| Genotype | Controls (n=381‡) | Minimally adjusted* |
Multivariate† |
||
|---|---|---|---|---|---|
| Mean change§ (95% CI) | % Difference ∥ (p-value) | Mean change§ (95% CI) | % Difference ∥ (p-value) | ||
| TTPA | |||||
| −980T>A | |||||
| AA | 137 | 6.6 (6.0−7.2) | Referent | 6.7 (6.1−7.2) | Referent |
| AT | 171 | 5.6 (5.1−6.2) | −15.2 (0.02) | 5.6 (5.0−6.1) | −16.4 (0.005) |
| TT | 69 | 5.1 (4.3−5.9) | −22.7 (0.005) | 5.0 (3.2−6.8) | −25.4 (0.002) |
| IVS1−5411G>T | |||||
| CC | 336 | 5.9 (5.5−6.3) | Referent | 5.8 (5.5−6.2) | Referent |
| AC | 26 | 5.0 (3.6−6.3) | −15.3 (0.20) | 5.2 (3.9−6.5) | −10.3 (0.37) |
| AA | 2 | 5.2 (0.40−10.1) | −11.9 (0.79) | 4.9 (0.3−9.6) | −15.5 (0.71) |
| IVS2−2372T>C | |||||
| CC | 251 | 6.0 (5.6−6.4) | Referent | 6.1 (5.6−6.5) | Referent |
| CT | 110 | 5.7 (5.1−6.4) | −5.0 (0.50) | 5.5 (4.9−6.2) | −9.8 (0.17) |
| TT | 16 | 5.3 (3.6−7.0) | −11.7 (0.44) | 5.0 (3.2−6.8) | −18.0 (0.26) |
| IVS2−2191A>G | |||||
| TT | 295 | 5.9 (5.5−6.3) | Referent | 5.9 (5.5−6.3) | Referent |
| CT | 61 | 5.8 (4.9−6.7) | −1.7 (0.82) | 5.9 (5.0−6.8) | 0 (0.99) |
| CC |
8 |
6.0 (3.5−8.4) |
1.7 (0.98) |
6.2 (3.8−8.6) |
5.1 (0.76) |
| SEC14L2 | |||||
| EX1−23G>A R11K | |||||
| GG | 130 | 6.0 (5.4−6.6) | Referent | 5.9 (5.3−6.5) | Referent |
| AG | 183 | 5.8 (5.3−6.3) | −3.3 (0.58) | 5.8 (5.3−6.3) | −1.7 (0.72) |
| AA | 65 | 6.0 (5.1−6.8) | 0 (0.99) | 6.1 (5.2−6.9) | 3.4 (0.73) |
| IVS1+111G>A | |||||
| GG | 156 | 6.0 (5.4−6.5) | Referent | 6.0 (5.4−6.5) | Referent |
| AG | 165 | 5.8 (5.2−6.3) | −3.3 (0.57) | 5.7 (5.2−6.2) | −5.0 (0.50) |
| AA | 49 | 6.2 (5.2−7.2) | 3.3 (0.71) | 6.2 (5.3−7.3) | 3.3 (0.57) |
| IVS2+182A>G | |||||
| GG | 240 | 6.1 (5.6−6.5) | Referent | 6.2 (5.7−6.6) | Referent |
| AG | 121 | 5.6 (4.9−6.2) | −8.2 (0.17) | 5.4 (4.8−6.0) | −12.9 (0.05) |
| AA | 13 | 5.3 (3.4−7.2) | −13.1 (0.44) | 4.6 (2.7−6.5) | −25.8 (0.11) |
| IVS11+931A>G | |||||
| AA | 272 | 5.9 (5.5−6.3) | Referent | 5.8 (5.4−6.2) | Referent |
| AG | 86 | 5.8 (5.1−6.6) | −1.7 (0.95) | 5.9 (5.2−6.6) | 1.7 (0.90) |
| GG | 10 | 6.8 (4.7−9.0) | 15.3 (0.40) | 6.4 (4.4−8.5) | 10.3 (0.58) |
| IVS11+1032C>T | |||||
| CC | 278 | 5.9 (5.5−6.3) | Referent | 5.9 (5.5−6.3) | Referent |
| CT | 88 | 5.8 (5.0−6.5) | −1.7 (0.76) | 5.5 (4.8−6.3) | −6.8 (0.38) |
| TT | 8 | 6.6 (4.1−9.0) | 11.9 (0.60) | 6.9 (4.5−9.2) | 16.9 (0.44) |
| IVS11+1164−>G | |||||
| GG | 213 | 5.8 (5.3−6.3) | Referent | 5.7 (5.3−6.2) | Referent |
| G/del | 134 | 6.0 (5.4−6.6) | 3.4 (0.52) | 6.0 (5.4−6.6) | 5.3 (0.46) |
| del/del | 24 | 6.5 (5.0−7.9) | 12.1 (0.38) | 6.5 (5.1−7.9) | 14.0 (0.30) |
| IVS11−896A>T | |||||
| TT | 145 | 5.6 (5.0−6.2) | Referent | 5.4 (4.9−6.0) | Referent |
| AT | 175 | 6.1 (5.6−6.6) | 8.9 (0.19) | 6.2 (5.7−6.7) | 14.8 (0.04) |
| AA | 58 | 6.0 (5.1−6.9) | 7.1 (0.48) | 5.9 (5.0−6.8) | 9.3 (0.42) |
| EX12−201T>C | |||||
| TT | 153 | 6.0 (5.5−6.6) | Referent | 6.0 (5.4−6.5) | Referent |
| CT | 168 | 5.6 (5.1−6.1) | −6.7 (0.28) | 5.6 (5.0−6.1) | −6.7 (0.27) |
| CC | 53 | 6.2 (5.3−7.2) | 3.3 (0.71) | 6.4 (5.4−7.3) | 6.7 (0.49) |
| EX12−71G>A | |||||
| GG | 206 | 6.0 (5.5−6.5) | Referent | 6.0 (5.6−6.5) | Referent |
| AG | 141 | 5.5 (4.9−6.1) | −8.3 (0.15) | 5.4 (4.8−6.0) | −10.0 (0.11) |
| AA | 26 | 6.8 (5.4−8.1) | 13.3 (0.30) | 6.7 (5.4−8.1) | 11.7 (0.34) |
Adjusted for baseline serum α-tocopherol levels
Further adjusted for age, body mass index, serum cholesterol concentrations, serum β-carotene concentrations, education, prior vitamin E supplement use, and daily dietary intakes of α-tocopherol, fruit, vegetables, and energy.
4 out of 385 controls were identified as outliers and excluded from these analyses
From generalized linear models
Percent difference calculated as 100 × [(mean change in serum α-tocopherol concentrations for heterozygote or recessive homozygote - mean change in serum α-tocopherol concentrations for wild-type homozygote) / (mean change in serum α-tocopherol concentrations for wild-type homozygote)]