TABLE 2.
Genotype Distributions and Allele Frequencies of the Subjects
| Frequency |
|||||
| Genotype/allele | Male, n (%) | Female, n (%) | p Value | Nonsmokers, n = 43 (%) | All subjects, n = 49 (%) |
| CYP2E1 (Val179Ile) | |||||
| Val/Val | 14 (77.8) | 30 (96.8) | 39 (90.7) | 44 (89.8) | |
| Val/Ile | 4 (22.2) | 1 (3.2) | 4 (9.3) | 5 (10.2) | |
| Ile/Ile | 0 (0.0) | 0 (0.0) | 0.054 | 0 (0.0) | 0 (0.0) |
| Val/Ile + Ile/Ile | 4 (22.2) | 1 (3.2) | 4 (9.3) | 5 (10.2) | |
| CYP2E1 (Phe421Phe) | |||||
| Phe/Phe (C/C) | 11 (61.1) | 21 (67.7) | 30 (69.8) | 32 (65.3) | |
| Phe/Phe (T/C) | 6 (33.3) | 6 (19.4) | 10 (23.3) | 12 (24.5) | |
| Phe/Phe (T/T) | 1 (5.6) | 4 (12.9) | 0.542 | 3 (7.0) | 5 (10.2) |
| Phe/Phe (C/T+T/T) | 7 (38.9) | 10 (32.3) | 13 (30.2) | 17 (34.7) | |
| EPHX1 (Tyr113His) | |||||
| Tyr/Tyr | 7 (38.9) | 21(67.7) | 27 (62.8) | 28 (57.1) | |
| Tyr/His | 8 (44.4) | 8 (25.8) | 12 (27.9) | 16 (32.7) | |
| His/His | 3 (16.7) | 2 (6.5) | 0.812 | 4 (9.3) | 5 (10.2) |
| Tyr/His + His/His | 11 (61.1) | 10 (32.3) | 16 (37.2) | 21 (42.9) | |
| EPHX1 (His139Arg) | |||||
| His/His | 14 (77.8) | 19 (61.3) | 27 (62.8) | 33 (67.3) | |
| His/Arg | 3 (16.7) | 9 (29.0) | 12 (27.9) | 12 (24.5) | |
| Arg/Arg | 1 (5.6) | 3 (9.7) | 0.790 | 4 (9.3) | 4 (8.2) |
| His/Arg + Arg/Arg | 4 (22.3) | 12 (38.7) | 16 (37.2) | 16 (32.7) | |
| GSTP1 (Ile105Val) | |||||
| Ile/Ile | 7 (38.9) | 18 (58.1) | 23 (53.5) | 25 (51.0) | |
| Ile/Val | 8 (44.4) | 8 (25.8) | 13 (30.2) | 16 (32.7) | |
| Val/Val | 3 (16.7) | 5 (16.1) | 0.375 | 7 (16.3) | 8 (16.3) |
| Ile/Val + Val/Val | 11 (61.1) | 13 (41.9) | 20 (46.5) | 24 (49.0) | |
| GSTM1 | |||||
| Positive | 13 (72.2) | 27 (87.1) | 37 (86.0) | 40 (81.6) | |
| Null | 5 (27.8) | 4 (12.9) | 0.259 | 6 (14.0) | 9 (18.4) |
| GSTT1 | |||||
| Positive | 11 (61.1) | 13 (41.9) | 23 (53.5) | 24 (49.0) | |
| Null | 7 (38.9) | 18 (58.1) | 0.244 | 20 (46.5) | 25 (51.0) |
Note. There are no significant differences in genotype frequencies between genders, and also no significant differences in genotype distributions between the nonsmokers subjects and all subjects.