TABLE 2.

Categorization of Antioxidant, Phase-I, Phase-II, and Transporter mRNA Expression

Pattern 1			Pattern 2			Pattern 3
Decrease in Nrf2-null mice and increase in Keap1-kd mice			Decrease in Nrf2-null mice and nonsignificant change in Keap1-kd mice			No changes among genotypes
Gene	Nrf2-null % change	Keap1-kd % change	Gene	Nrf2-null % change	Keap1-kd % change	Gene
Gstp2*	−40	586	Ugp2	−29	16	Ho-1
Gsta1	−84	448	Ces1b4	−14	16	Gpx
Gstm3	−81	336	Ugt2b36	−66	12	Pon1
Nqo1	−88	222	Txn1	−23	9	Pon3
Gstm1	−74	140	Aldh7a1	−13	8	Aldh1b1
Mrp3	−85	111	Oct1	−25	8	Aldh2
Gstm4	−67	102	H6pdh	−16	7	Aldh4a1
Ugdh	−50	75	Prx1	−20	6	Aldh8a1
Gstm2	−57	65	Ces1d1	−38	4	Aldh9a1
Gclc	−37	63	Cat	−15	4	Ugt1a1
Ces1e1	−94	59	Oatp1b2	−25	1	Ugt1a5
Mrp4*	−3	55	Ugt2b34	−35	0	Ugt2a3
Gsta4	−53	45	Ugt2b1	−32	−1
Abcg5	−29	45	Glrx1	−27	−1	Gstt1
Abcg8	−20	40	Sod1	−10	−2	Gstt2
Ces2a6	−85	38	Ugt1a9	−47	−3	mGst1
Ugt2b35	−79	32	Ces1h1	−54	−3	mGst2
Mrp2	−17	24	Aldh6a1	−21	−3	mGst3
Ugt1a6	−46	23	Aldh1a1	−32	−4	Sult1a1
Txnrd1	−41	23	Aldh1a7	−23	−5	Sult1d1
Gclm	−16	22	Aldh3a2	−25	−6	Papps1
Gsr	−23	17	Ugt3a2	−31	−11	Oat2
Bcrp	−27	16	Sod2	−32	−14	Oatp1a4
			Mate1	−26	−15	Oatp2b1
			Me1	−62	−18	Ent1
			Eh-1	−72	−18	Ntcp
			Oatp1a1	−17	−35	Mdr2
						Mrp6
						Abca1
						Bsep

Note. Percent change from wild-type in Nrf2-null and Keap1-kd mice are presented. The first pattern represents genes that had significant decrease in Nrf2-null mice (p ≤ 0.05) and a significant increase in Keap1-kd mice (p ≤ 0.05). The second pattern represents genes that had significant decrease in Nrf2-null mice (p ≤ 0.05) and no change from wild-type in Keap1-kd mice (p > 0.05). The third pattern of gene expression represents genes that were not different among wild-type, Nrf2-null, and Keap1-kd mice. *No significant difference between Nrf2-null and wild-type mice (p > 0.05).