FIG. 1.
SLD dose-response in the absence and presence of LPS. Rats were treated with various doses of SLD (10, 20, 50, 100, or 300 mg/kg, p.o.) or its vehicle (0.5% methyl cellulose) at −16 h, and food was removed. At −0.5 h rats received LPS (8.25 × 105 EU/kg, i.v.) or its vehicle (saline), and 30 min later they were given a second administration (same dose as first administration) of SLD. Blood samples were taken at 12 h after the second administration of SLD, and ALT activity was measured. *Significantly different from SLD/Veh group at the same dose. p < 0.05, n = 3.