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Development of hepatocellular injury induced by SLD/LPS cotreatment. Rats were treated with SLD (50 mg/kg, p.o.) or its vehicle (0.5% methyl cellulose) and LPS or its vehicle as described in Figure 1. Blood samples were taken at various times (0, 1, 2, 4, 8, 12, or 24 h), and ALT (A) and AST (B) activities in serum were measured. *Significantly different from all other groups at the same time. #Significantly different from SLD/LPS group at 0 h. p < 0.05, n = 5–10.
