TABLE 1.

Midzonal Hepatic Necrosis in Livers of Rats Treated with SLD/LPS

Treatment	Time after 2nd SLD (h)
	4	8	12	24
Veh/Veh	0.50 (0.34–0.53)	0.50 (0.31–0.66)	0.44 (0.25–0.63)	0.63 (0.47–0.66)
SLD/Veh	0.38 (0.34–0.88)	0.88 (0.47–1.03)	0.75 (0.63–1.00)	0.75 (0.44–0.88)
Veh/LPS	0.75 (0.47–0.97)	0.75 (0.56–1.19)	0.63 (0.44–1.09)	1.00 (0.81–1.26)
SLD/LPS	0.88 (0.72–1.40)	1.88 (1.63–3.59)*	3.37 (2.25–3.88)*	2.88 (2.25–3.38)*

Note. Liver sections from rats killed at 4, 8, 12, and 24 h after the second administration of SLD were evaluated and assigned a score of 0–5 as described under Materials and Methods. Data are expressed as median score and 25th and 75th quartiles. *Significantly different from Veh/Veh group at the same time. p < 0.05, n = 5–10.