TABLE 1.
Reference | Ascertainment Source | Location | Sample Size | Relative Risk | Cumulative Incidence, % |
---|---|---|---|---|---|
Watson & Lynch 199343 | 1300 High-risk members from 23 HNPCC kindreds | Nebraska | 13 | 3.5 | - |
Aarnio 199542 | 293 Putative HNPCC gene carriers from 40 families | Finland | 14 | - | 9 |
Vasen 199641 | 382 Relatives from 19 families with HNPCC mutations | Netherlands | 2 | 8 | - |
Aarnio 199945 | 1763 High-risk members from 50 HNPCC families | Finland | 13 | 13 | 12 |
Brown 200144 | 120 HNPCC families | Australia | 24 | 5 (by age 40 y) | - |
HNPCC indicates hereditary nonpolyposis colorectal cancer.