Table 1.
Compounds | R1 | R2 | R3 | EC50 (glutamate toxicity) |
---|---|---|---|---|
1 4β-(S-aminoethylthio)epicatechin (Cya- EC) |
H | OH | SCH2CH2NH3 + | 6 |
1 4β-(S-aminoethylthio)epicatechin-3-O- gallate (Cya-ECG) |
H | gallate | SCH2CH2NH3 + | 9 |
1 4β-(S-aminoethylthio)epigallocatechin (Cya-EGC) |
OH | OH | SCH2CH2NH3 + | 12 |
1 4β-(S-aminoethylthio)epigallocatechin- 3-O-gallate (Cya-EGCG) |
OH | gallate | SCH2CH2NH3 + | 20 |
2 4β-(S-cysteinyl)epicatechin (Cys-EC) | OH | NH3 + | O− | 40 |
2 4β-[(S-(O-ethyl-cysteinyl)]epicatechin (ECys-EC) |
OH | NH3 + | OCH2CH3 | 36 |
2 4β-[(S-(N-acetyl-O-methyl- cysteinyl)]epicatechin (AMCys-EC) |
OH | NHCOCH3 | OCH3 | 50 |
gallate: