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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Structure. 2008 Nov 12;16(11):1616–1625. doi: 10.1016/j.str.2008.10.002

Figure 2. The Many Faces of Mad2.

Figure 2

Ribbon diagrams of N1/open Mad2DC (O-Mad2; PDB ID 1DUJ) (A), N2/closed Mad2-bound to MBP1 (C-Mad2; PDB ID 1KLQ) (B), unliganded C-Mad2R133A (PDB ID 1S2H) (C), the symmetric C-Mad2L13A–C-Mad2L13A dimer (PDB ID 2VFX) (D), and the asymmetric O-Mad2LL –C-Mad2 dimer (PDB ID 2V64) (E). MBP1 is a non-natural high-affinity Mad2-binding peptide identified through phage display (Luo et al., 2002). Loop-less Mad2 (Mad2LL) is a Mad2 mutant with the β5-αC loop shortened (Mapelli et al., 2007).