Fig. (6).

Effect of intrathecal administration of PD98059 on bladder reflex activity in animals with intact and chronically transected spinal cord. In animals with intact cords, PD98059 had no effect in bladder contractions,despite the amount of inhibitor injected. In animals that underwent chronic spinal cord transection at high thoracic levels, bladder reflex activity is clearly altered. These animals display high frequency of bladder contractions with strong micturition pressures. PD98059 visibly reduced both the frequency and amplitude of bladder contractions (Cruz et al., unpublished results).