TABLE 1.
Comparative μCT analysis
| A. Cross-sectional cortical properties at femoral mid-shaft | ||||
|---|---|---|---|---|
| Females | Males | |||
| Control | Hip/Rpl29−/− % reduction vs. control | Control | Hip/Rpl29−/− % change vs. control | |
| Outer Perimeter (mm) | 4.67 (+/−0.144) | 4.24 (+/−0.258) −9.2% | 5.53 (+/−0.506) | 4.76 (+/−0.188) −13.9% |
| Inner Perimeter (mm) | 3.03 (+/−0.145) | 2.74 (+/−0.293) −9.6% | 4.08 (+/−0.568) | 3.21 (+/−0.191) −21.3% |
| Marrow Area (mm2) | 0.65 (+/−0.06) | 0.54 (+/−0.12) −17.2% | 1.13 (+/−0.31) | 0.70 (+/−0.07) −38.1% |
| Cortical Area (mm2) | 0.99 (+/−0.05) | 0.80 (+/−0.07) −19.0% | 1.08 (+/−0.22) | 0.96 (+/−0.06) −11.0% n.s. |
| A/P bone diameter (Depth, mm) | 1.556 (+/−0.07) | 1.40 (+/−0.06) −9.7% | 1.76(+/−0.21) | 1.50(+/−0.07) −14.8% |
| M/L bone diameter (Width, mm) | 2.20 (+/−0.06) | 1.98(+/−0.16) −9.9% | 2.68(+/−0.22) | 2.33(+/−0.14) −13.2% |
| Cortical width, (CTW, mm) | 0.30 (+/−0.02) | 0.28 (+/−0.02) −7.6% | 0.30(+/−0.03) | 0.30(+/−0.01) No change. |
| IML(=Ixx, mm4) | 0.277 (+/−0.035) | 0.176 (+/−0.042) −36.5% | 0.463(+/−0.068) | 0.234 (+/−0.048) −49.5% |
| IAP (=Iyy, mm4) | 0.566 (+/−0.068) | 0.359 (+/−0.103) −36.6% | 0.947(+/−0.204) | 0.521(+/−0.074) −55% |
| BMD (mg/cm3) | 883 (+/−21) | 861 (+/−26) −2.5% | 976 (+/−22) | 1018 (+/−19) +4.3% |
| Total tissue area (mm2) | 1.64(+/−0.1) | 1.34(+/0.15) −18.3% | 2.21(+/−0.34) | 1.66(+/−0.12) −24.9% |
| B. Trabecular properties of distal femora | ||||
|---|---|---|---|---|
| Females | Males | |||
| Control | Hip/Rpl29−/− (%change vs. Control) | Control | Hip/Rpl29−/− (%change vs. Control) | |
| BV/TV | 0.177(+/− 0.029) | 0.158(0.028) −10.7% | 0.254(+/−0.029) | 0.302 (+/− 0.041) |
| Trabecular thickness (Tb. Th, μm) | 68 (+/− 9.8) | 59 (+/− 9.9) −12.4% | 71 (+/− 5.8) | 76 (+/−6.2) +7.2% |
| Trabecular number (Tb. N/mm) | 2.65 (+/−0.21) | 2.66 (+/−0.24) No change | 3.62 (+/− 0.48) | 3.96 (+/−0.37) +9.6% |
| Trabecular Separation (Tb. Sp, μm) | 312 (+/− 32.1) | 319 (+/− 35.9) No change | 210 (+/−39.5) | 178 (+/−28.8) −15.1% |
| BMD (mg/cm3) | 247 (+/−23) | 214 (+/−21) −13.4% | 347 (+/−13) | 363 (+/−35) +4.6% n.s. |
| TMD (mg/cm3) | 582 (+/−40) | 529 (+/−40) −9.1% | 533 (+/−71) | 578 (+/−60) +8.4 n.s. |
| Total volume (TV, mm3) | 2.34 (+/−0.12) | 1.96 (+/− 0.19) −16.6% | 3.32 (+/− 0.5) | 2.49 (+/− 0.19) −25% |
%
change in bold are significant p < 0.05. n.s, non-significant. Data are mean ±std dev.