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. Author manuscript; available in PMC: 2009 Dec 5.
Published in final edited form as: J Mol Biol. 2008 Sep 16;384(1):151–164. doi: 10.1016/j.jmb.2008.09.009

Table 1.

Influence of L201P substitution on TEM-1 β-lactamase mediated MIC levels.

Ampa Amox+CVb
TEM-1 2048 24
L76N 32 6
M182T 2048 24
L201P 2048 24
R244A 256 32
M182T:L201P 2048 16
L201P:R244A 256 64
L76N:M182T 512 16
L76N:L201P 64 12
L76N:M182T:L201P 1024 16
a

µg/ml ampicillin using broth dilution, pBG66 plasmid

b

µg/ml amoxicillin with clavulanic acid in 2:1 ratio using E-test strip, pBG66 plasmid