Table 2.
GRSN aids Gene Set Enrichment Analysis (GSEA).
| SS dataset (mutant vs. control) | Without GRSN | With GRSN | ||
| Pathway | NES | FDR | NES | FDR |
| CR_CYTOSKELETON [28,29] | 0.9053 | 0.6021 | 1.2209 | 0.2131 |
| vegfPathway [24] | Not found | 1.1346 | 0.2775 | |
| cell_adhesion [30] | Not found | 0.9004 | 0.6332 | |
| RS dataset (Myc vs. control) | Without GRSN | With GRSN | ||
| Pathway | NES | FDR | NES | FDR |
| Cell_Cycle [31] | 1.6516 | 0.1171 | 1.7633 | 0.0240 |
| CR_CELL_CYCLE [31] | 1.5565 | 0.1221 | 1.6751 | 0.0488 |
| G1_CELL_CYCLE [31] | 1.6902 | 0.1461 | 1.6913 | 0.0398 |
| DNA_DAMAGE_SIGNALLING [32] | 1.5355 | 0.1353 | 1.6632 | 0.0490 |
| cell_proliferation [31] | 1.6101 | 0.1161 | 1.6207 | 0.0884 |
| cell_cycle_checkpoint [31] | 1.4528 | 0.1941 | 1.5852 | 0.1192 |
| PROLIF_GENES [31] | 1.5104 | 0.1539 | 1.5745 | 0.1139 |
| cell_growth_and_or_maintenance [33] | 1.4340 | 0.1984 | 1.5681 | 0.1099 |
| HTERT_UP [33] | 1.4436 | 0.2064 | 1.5566 | 0.1066 |
| cellcyclePathway [31] | 1.4618 | 0.1887 | 1.4981 | 0.1357 |
| CR_DEATH [34] | 0.9966 | 0.5629 | 1.2257 | 0.3680 |
GSEA is applied to the SS and RS datasets. Pathways known to be active in these datasets are shown and referenced. For each selected pathway, the Normalized Enrichment Score (NES) and the False Discovery Rate (FDR), as reported by GSEA, are shown. NES and FDR values are shown both for data processed with RMA alone (Without GRSN) and for data processed with RMA followed by GRSN (With GRSN) as indicated.