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Relative VKOR activities of different rat VKORC1 variants after recombinant expression in HEK293 cells. Light grey bars indicate basal VKOR activities of the variants in the absence of warfarin; dark grey bars show VKOR activities after addition of 60 μM warfarin. The specific activity of the recombinant rat wild-type enzyme (WT) was 1.0 ± 0.37 nmoles/mg protein × h and was set to 100% for comparison. Standard deviations are indicated by black error bars.
