Table 3.
Overview of mutations found in VKORC1 in rats, mice and humans.
| Rattus norvegicus | NCBI_ss# |
Mus musculus/ Mus domesticus |
Homo sapiens |
Reference |
| Arg12Arg | 107794658 | -- | -- | this study |
| -- | -- | Arg12Trp | -- | this study |
| Ala21Thr | 107794659 | -- | -- | this study |
| Ala26Thr | 107794660 | Ala26Ser | -- | this study |
| -- | -- | -- | Val29Leu | [3] |
| Arg33Pro | 107794661 | -- | -- | [13]; this study |
| Arg35Pro | 107794662 | -- | -- | [14]; this study |
| -- | -- | Glu37Gly | -- | this study |
| Tyr39Asn | 107794663 | -- | -- | this study |
| -- | -- | -- | Val45Ala | [3] |
| -- | -- | Ala48Thr | -- | this study |
| Ser56Pro | 107794664 | -- | -- | this study |
| -- | -- | Arg58Gly | Arg58Gly | [3]; this study |
| Trp59Arg | 107794665 | -- | -- | this study |
| -- | -- | Arg61Leu | -- | this study |
| -- | -- | -- | Val66Met | [28] |
| Phe63Cys | 107794666 | -- | -- | this study |
| Glu67Lys | 107794667 | -- | -- | this study |
| Ile82Ile | 107794668 | -- | -- | this study |
| Ile90Leu | 107794669 | -- | -- | this study |
| Leu94Leu | 107794670 | -- | -- | this study |
| Ser103Ser | 107794671 | -- | -- | this study |
| Ile107Ile | 107794672 | -- | -- | this study |
| Val112Leu | 107794673 | -- | -- | this study |
| Leu120Gln | 107794674 | -- | -- | [14] |
| Leu128Gln | 107794675 | Leu128Ser | Leu128Arg | [3,14]; this study |
| Thr137Thr | 107794676 | -- | -- | this study |
| Tyr139Phe | 107794677 | -- | -- | [14,29]; this study |
| Tyr139Cys | 107794678 | Tyr139Cys | -- | [3,14]; this study |
| Tyr139Ser | 107794679 | Tyr139Ser | -- | [14]; this study |
| Ile141Val | 107794680 | -- | -- | this study |
| Ala143Ala | 107794681 | -- | -- | this study |
| Ala143Val | 107794682 | -- | -- | this study |
Mutations in bold indicate where resistance was proven in rats or mice, or dosing problems in humans were reported. All sequence variants found in rats were submitted to dbSNP at NCBI http://www.ncbi.nlm.nih.gov/sites/entrez and are indicated by their distinct NCBI_ss# numbers.