Table 4.
Distribution of non-synonymous mutations within the predicted V1R protein structure.
| Domain | Conserved (21) | dS/dN > 2 (6) | dS/dN < 1 (2) |
| E1 (23) | 0.72 | 2.17 | |
| TM1 (12) | G24,N28,L31 | 1.39 | 20.83 |
| I1 (14) | 2.38 | 0.00 | |
| TM2 (22) | L60,L63 | 1.52 | 0.00 |
| E2 (25) | D72,W80,C85,R96 | 1.33 | 2.00 |
| TM3 (22) | L106,L114 | 0.00 | 6.82 |
| I2 (13) | K125 | 1.28 | 0.00 |
| TM4 (23) | Y143 | 5.07 | 2.17 |
| E3 (39) | N159,C172,R192 | 0.85 | 2.56 |
| TM5 (18) | L211 | 0.93 | 2.78 |
| I3 (26) | L221,S227,A236 | 5.77 | 9.62 |
| TM6 (20) | 4.17 | 2.50 | |
| E4 (17) | R261 | 0.98 | 8.82 |
| TM7 (16) | 1.04 | 0.00 |
The size (number of amino acid residues, brackets) of predicted domains structures (E = extracellular, I = intracellular, TM = transmembrane) and the locations of the 21 most conserved amino-acid residues in rodent V1R proteins are shown. The incidence of non-synonymous mutations in six orthologous gene pairs (MUS.A6-YUA.3, MUS.B9-YUA.4, MUS.B4-YUB.4, MUS.A2-YUB.6, MUS.B1-YUC.3, and MUS.A1-YUC.5) with dS/dN > 2 (presumed purifying selection) were compared to two orthologous gene pairs (MUS.A5-YUB.2 and MUS.B2-YUC.1) with dS/dN < 1 (presumed adaptive selection). Numbers shown are the incidence of occurrence (observed percent mutations/opportunities) within a particular structural domain (outliers are bolded).