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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Pain Med. 2008 Sep 24;10(1):133–142. doi: 10.1111/j.1526-4637.2008.00513.x

Table 1.

Bridging the gap between experimentally induced rodent models of bone cancer and clinical bone cancer with the study of novel therapeutics in companion dogs with spontaneous bone cancer.

Rodents Companion Dogs Patients
Disease Induced Spontaneous Spontaneous
Progression Rapid (days-weeks) Intermediate (months) Slow (months-years)
Evaluation Tools Induced Pain via: Spontaneous Pain via: Spontaneous Pain via:
hot plate Canine Brief Pain Inventory: Brief Pain Inventory:
cold plate severity severity
von Frey interference interference
rotarod quality of life quality of life