Figure 1.—

(A) Comparative similarity between Saccharomyces cerevisiae Prm1p and Neurospora crassa PRM1. Regions of higher similarity are shown as darker on the scale. Shaded bars at the bottom of each sequence represent predicted transmembrane domains, while the solid bar indicates the predicted signal peptide in Prm1p. For N. crassa PRM1, transmembrane domains are represented as H1–H5 in B. (B) Depicts the predicted topology of the five predicted transmembrane helixes in N. crassa PRM1. PRM1 has a predicted extracellular N-terminal region and intracellular C-terminal region.