Table 1.

Modulation of expression and secretion of molecules by LPLI

Classification	Molecules	Biological effects of LPLI
Growth factors	BDNF, GDNF, bFGF, IGF-I, KGF, PDGF, TGF-β, VEGF	Proliferation, Differentiation, Bone nodule formation
Interleukins	IL-1α, IL-6, IL-8, IL-2, IL-4	Proliferation, Migration, Immunological activation
Inflammatory cytokines	PGE2, COX-2, IL-1β, TNF-α	Inhibition of inflammation
Small molecules	ATP, cGMP, ROS, Ca2+, NO	Normalization of cell function, Pain relief, Healing, Mediating cell activities, Migration, Angiogenesis