Fig. 5.

Plasma insulin in response to a test meal. Chronic caloric restriction resulted in altered patterns of plasma insulin in rats that had undergone chronic restriction and weight restoration. A: baseline plasma insulin levels were significantly lower in CR compared with control rats. In controls, plasma insulin was significantly increased 30 min after the onset of the test meal (P < 0.05). It remained significantly elevated through the 60-min time point and returned to a value that was not different from baseline at the 120-min measurement. CR insulin was significantly elevated compared with CR baseline at 15 min (P < 0.05) and remained so for the entirety of the test session. B: PR insulin was significantly elevated compared with baseline PR insulin at the 30-min time point, remained so at 60 min, and returned to baseline levels at 120 min. C: FR insulin was increased compared with FR baseline insulin 15 min after the start of the meal and remained elevated for the duration of the test session (P < 0.05). FR insulin at 120 min was also significantly higher than control insulin at this time point. D: the area under the curve (AUC) for CR rats was significantly lower than for controls (P < 0.05). *P < 0.05 compared with controls.