Table 2.
Prevalence of drug resistance to first line antituberculosis at 4 sentinel sites in Georgia, 2001-2004
| Resistance Profile | All Cases | New Cases | Retreatment Cases |
Unknown Treatment History |
||||
|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | N | % | |
| Total number of strains tested |
931 |
100.0 |
534 |
100.0 |
388 |
100.0 |
9 |
100.0 |
| I. Any drug resistance a | 596 | 64.0 | 258 | 48.3 | 331 | 85.3 | 7 | 77.8 |
| Isoniazid (INH) | 442 | 47.5 | 159 | 29.8 | 280 | 72.2 | 3 | 33.3 |
| Rifampin (RIF) | 287 | 30.8 | 66 | 12.4 | 220 | 56.7 | 1 | 11.1 |
| Streptomycin (SM) | 490 | 52.6 | 199 | 37.3 | 284 | 73.2 | 7 | 77.8 |
| Ethambutol (EMB) | 210 | 22.7 | 56 | 10.5 | 154 | 39.7 | 0 | 0 |
| II. Monoresistance b | 188 | 20.2 | 126 | 23.6 | 59 | 15.2 | 3 | 33.3 |
| INH only | 59 | 6.3 | 39 | 7.3 | 20 | 5.2 | 0 | 0 |
| RIF only | 7 | 0.8 | 3 | 0.6 | 4 | 1.0 | 0 | 0 |
| SM only | 108 | 11.6 | 75 | 14.0 | 30 | 7.7 | 3 | 33.3 |
| EMB only | 14 | 1.5 | 9 | 1.7 | 5 | 1.3 | 0 | 0 |
| III. MDR-TBa | 262 | 28.1 | 56 | 10.5 | 206 | 53.1 | 0 | 0 |
| INH + RIF | 15 | 1.6 | 6 | 1.1 | 9 | 2.3 | 0 | 0 |
| INH + RIF + EMB | 6 | 0.6 | 0 | 0 | 6 | 1.6 | 0 | 0 |
| INH + RIF + SM | 98 | 10.5 | 26 | 4.9 | 72 | 18.5 | 0 | 0 |
| INH + RIF + SM + EMB | 143 | 15.4 | 24 | 4.5 | 119 | 30.7 | 0 | 0 |
| IV. Polyresistance c | 146 | 15.7 | 76 | 14.2 | 66 | 17.0 | 4 | 44.4 |
| INH + EMB | 2 | 0.2 | 1 | 0.2 | 1 | 0.3 | 0 | 0 |
| INH + SM | 86 | 9.2 | 48 | 9.0 | 35 | 9.0 | 3 | 33.3 |
| INH + EMB + SM | 33 | 3.5 | 15 | 2.8 | 18 | 4.6 | 0 | 0 |
| RIF + EMB | 3 | 0.3 | 1 | 0.2 | 2 | 0.5 | 0 | 0 |
| RIF + SM | 13 | 1.4 | 5 | 0.9 | 7 | 1.8 | 1 | 11.1 |
| RIF + EMB + SM | 2 | 0.2 | 1 | 0.2 | 1 | 0.3 | 0 | 0 |
| EMB + SM | 7 | 0.7 | 5 | 0.9 | 2 | 0.5 | 0 | 0 |
|
Number of drugs resistant to: |
||||||||
| Susceptible to 4 drugs | 335 | 36.0 | 276 | 51.7 | 57 | 14.7 | 2 | 22.2 |
| Resistance to 1 drug | 188 | 20.2 | 126 | 23.6 | 59 | 15.2 | 3 | 33.3 |
| Resistance to 2 drugs | 126 | 13.5 | 66 | 12.3 | 56 | 14.4 | 4 | 44.4 |
| Resistance to 3 drugs | 139 | 14.9 | 42 | 7.9 | 97 | 25.0 | 0 | 0 |
| Resistance to 4 drugs | 143 | 15.4 | 24 | 4.5 | 119 | 30.7 | 0 | 0 |
INH=isoniazid; RIF=rifampin; EMB=ethambutol; SM=streptomycin MDR-TB=multidrug-resistant tuberculosis (resistance to at least both isoniazid and rifampin) Polyresistance=resistance to two or more drugs but not both isoniazid and rifampin
a
p<0.001 in Chi-square test for comparison of prevalence of resistance pattern among retreatment cases to that among new cases
b
p=0.002 in Chi-square test for comparison of prevalence of resistance pattern among retreatment cases to that among new cases
c
p=0.25 in Chi-square test for comparison of prevalence of resistance pattern among retreatment cases to that among new cases.