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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Neuropharmacology. 2008 Sep 10;55(8):1321–1328. doi: 10.1016/j.neuropharm.2008.08.031

Figure 2. Development and stability of dyskinesia and contralateral rotations upon D1R agonist treatment.

Figure 2

Rats (n=36) in the first experiment received treatment injections of the D1R agonist SKF81297 (0.8 mg/kg, sc) on 3 separate occasions 2–3 days apart in order to sensitize D1R. ALO AIMs and contralateral rotations were observed immediately after injections and summed over 2 hr. In order to determine stability of these behaviors, a post-test with SKF81297 was included following completion of pharmacological treatments. Lines depict mean scores ± SEM of ALO AIMs and contralateral rotations. Effects over time were determined by repeated-measures non-parametric Friedman ANOVA for ALO AIMs and repeated-measures parametric ANOVA for rotations. Post hoc analyses denote significant differences between exposure times. * p < 0.05 vs Priming 1; + p < 0.05 vs Priming 2