Table 2.
Baseline Characteristics of Women and Men With Nonmetastatic Colorectal Cancer According to Quartile of Prediagnosis Plasma IGFBP-1
| Characteristic | Quartiles of Plasma IGFBP-1
|
P* | |||
|---|---|---|---|---|---|
| 1 (n = 94) | 2 (n = 92) | 3 (n = 92) | 4 (n = 90) | ||
| Median plasma IGFBP-1, ng/mL | 5.0 | 13.8 | 27.5 | 53.7 | — |
| Age, years | .02 | ||||
| Median | 69.0 | 67.0 | 70.0 | 71.0 | |
| SD | 7.4 | 7.8 | 6.9 | 7.8 | |
| Sex, % of patients | — | ||||
| Female | 63 | 63 | 64 | 64 | |
| Male | 37 | 37 | 36 | 36 | |
| Body mass index, kg/m2 | |||||
| Prediagnosis | < .001 | ||||
| Median | 28.1 | 26.0 | 24.6 | 23.7 | |
| SD | 5.5 | 3.4 | 3.7 | 3.4 | |
| Postdiagnosis | < .001 | ||||
| Median | 28.2 | 25.9 | 24.6 | 23.4 | |
| SD | 5.1 | 3.9 | 4.5 | 4.3 | |
| Activity level, MET-h/wk | |||||
| Prediagnosis | .75 | ||||
| Median | 14.0 | 14.1 | 11.5 | 20.7 | |
| SD | 24.2 | 25.6 | 39.5 | 25.3 | |
| Postdiagnosis | .61 | ||||
| Median | 10.6 | 8.9 | 10.1 | 10.2 | |
| SD | 26.1 | 16.8 | 22.2 | 26.9 | |
| Smoking status, % of patients | .18 | ||||
| Never | 38 | 43 | 39 | 46 | |
| Past | 44 | 50 | 42 | 44 | |
| Current | 18 | 7 | 19 | 10 | |
| Alcohol consumption, g/d | .43 | ||||
| Median | 2.0 | 2.3 | 2.0 | 3.4 | |
| SD | 11.5 | 13.4 | 10.6 | 12.8 | |
| Aspirin use, ≥ twice per week, % of patients | 23 | 34 | 32 | 32 | .42 |
| Postmenopausal hormone use, % of patients† | .01 | ||||
| Premenopausal | 8 | 21 | 9 | 7 | |
| Never used | 48 | 36 | 42 | 21 | |
| Current user | 17 | 21 | 29 | 48 | |
| Past user | 27 | 22 | 20 | 24 | |
| Regular multivitamin use, % of patients | 35 | 30 | 45 | 48 | .06 |
| Total vitamin D intake, U/d | .04 | ||||
| Median | 261.1 | 240.0 | 321.3 | 347.5 | |
| SD | 268.2 | 226.6 | 268.8 | 245.6 | |
| Tumor location, % of patients | .51 | ||||
| Colon | 81 | 74 | 72 | 74 | |
| Rectum | 19 | 26 | 28 | 26 | |
| Tumor differentiation, % of patients | .64 | ||||
| Well | 11 | 13 | 12 | 12 | |
| Moderate | 54 | 59 | 61 | 60 | |
| Poor | 13 | 5 | 13 | 12 | |
| Unknown | 22 | 23 | 14 | 16 | |
| Stage of disease, % of patients | .04 | ||||
| I | 23 | 34 | 34 | 37 | |
| II | 27 | 36 | 28 | 19 | |
| III | 26 | 16 | 24 | 32 | |
| Unknown | 24 | 14 | 14 | 12 | |
| Chemotherapy received, % of patients† | .93 | ||||
| Yes | 16 | 12 | 13 | 13 | |
| No | 14 | 12 | 10 | 10 | |
| Unknown | 70 | 76 | 77 | 77 | |
| No. of years between plasma collection and cancer diagnosis | .92 | ||||
| Median | 6.4 | 7.1 | 6.7 | 5.9 | |
| SD | 3.3 | 3.3 | 3.7 | 4.1 | |
Abbreviations: IGFBP-1, insulin-like growth factor binding protein-1; SD, standard deviation; MET, metabolic equivalent.
*
Covariates were analyzed using analysis of variance for continuous variables and χ2 tests for categorical variables.
†
Data are available for Nurses’ Health Study participants only.