Table 3.
Correlation of IL-7 Levels With Lymphocyte Counts Over Time
Level | Baseline | Day 0 | Day +7 | Day +14 | 1 Month | 2 Months | 3 Months | 6 Months | 9 Months | 12 Months |
---|---|---|---|---|---|---|---|---|---|---|
IL-7, pg/mL | ||||||||||
Median | 12.1 | 37.0 | 13.5 | 12.0 | 9.4 | 6.5 | 7.6 | 9.8 | 9.0 | 15.0 |
Range | 0-46.9 | 13.3-79.2 | 3.0-73.0 | 1.3-74.7 | 1.3-34.9 | 1.5-70.0 | 0.2-68.0 | 0-43.5 | 0-71.2 | 3.2-33.7 |
ALC, cells/μL | ||||||||||
Median | 871 | 3 | 76 | 493 | 1,138 | 1,028 | 1,014 | 1,298 | 1,600 | 1,220 |
Range | 95-43,817 | 0-322 | 6-525 | 9-2,904 | 149-3,172 | 145-5,564 | 110-3,606 | 147-4,140 | 207-3,909 | 229-5,494 |
R | −0.49 | −0.28 | −0.83 | −0.35 | −0.25 | −0.22 | −0.08 | −0.24 | −0.40 | −0.22 |
P | .008 | .14 | < .0001 | .06 | .18 | .27 | .66 | .30 | .06 | .36 |
CD3, cells/μL | ||||||||||
Median | 629 | 3 | 60 | 307 | 773 | 777 | 745 | 1003 | 1339 | 985 |
Range | 5-2,858 | 0-69 | 5-464 | 6-1,428 | 128-2,927 | 112-5,369 | 97-3,516 | 95-3,908 | 172-3,729 | 200-5,257 |
R | −0.52 | −0.28 | −0.82 | −0.36 | −0.39 | −0.22 | −0.14 | −0.25 | −0.38 | −0.33 |
P | .005 | .14 | < .0001 | .05 | .04 | .28 | .47 | .29 | .07 | .15 |
CD4, cells/μL | ||||||||||
Median | 294 | 3 | 45 | 206 | 405 | 310 | 352 | 439 | 494 | 440 |
Range | 5-1,652 | 0-65 | 5-385 | 5-810 | 75-1,145 | 78-901 | 40-1,493 | 35-1,457 | 70-1,176 | 33-1,032 |
R | −0.58 | −0.22 | −0.86 | −0.33 | −0.36 | −0.19 | −0.08 | −0.34 | −0.20 | −0.25 |
P | .001 | .24 | < .0001 | .07 | .05 | .36 | .66 | .14 | .34 | .29 |
CD8, cells/μL | ||||||||||
Median | 269 | 0 | 16 | 95 | 326 | 364 | 356 | 557 | 660 | 397 |
Range | 1-1,763 | 0-22 | 0-88 | 1-963 | 27-2,123 | 31-4,484 | 57-2,990 | 57-2,447 | 98-2,932 | 165-4,258 |
R | −0.54 | −0.35 | −0.65 | −0.48 | −0.32 | −0.22 | −0.16 | −0.22 | −0.46 | −0.22 |
P | .003 | .06 | .0002 | .006 | .09 | .27 | .39 | .36 | .02 | .34 |
NOTE. Correlation coefficients and P values shown are for comparison with interleukin-7 (IL-7) levels at specified time points.
Abbreviation: ALC, absolute lymphocyte count.