Table 1.
Potentiation of NorA substrates by 5′-MHC in inhibiting growth of S. aureus
Minimal inhibitory concentration, μg/ml
|
||||
---|---|---|---|---|
Wild type | NorA− | |||
Drug | + 5′-MHC, 10 μg/ml | + 5′-MHC, 10 μg/ml | ||
Norfloxacin | 1 | 0.25 | 0.25 | 0.25 |
EtdBr | 4 | 0.5 | 0.5 | 0.125 |
Tetraphenylphosphonium | 16 | 4 | 4 | 2 |
Pentamidine | 64 | 4 | 0.5 | 0.25 |
Benzalkonium chloride | 1 | 0.125 | 0.03125 | 0.0625 |
Berberine | 256 | 16 | 32 | 2 |
Palmatine | >256 | 64 | 64 | 2 |