Table 1.
Symptom Severity Cut Points, Onset Time, Severity, and Response by Trial Arm
| Symptom* and Intervention Arm | Onset Time†
|
Onset Severity | No. | % | Nonresponse
|
Response
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| First Contact
|
Second or Later Contact
|
||||||||||
| No. | % | No. | % | No. | % | No. | % | ||||
| Anxiety, 0-3, 4-5, 6-10 | |||||||||||
| NASM | 17 | 51.5 | 16 | 48.5 | Moderate | 21 | 63.6 | 9 | 42.9 | 12 | 57.1 |
| Severe | 12 | 36.4 | 2 | 16.7 | 10 | 83.3 | |||||
| ATSM | 24 | 80.0 | 6 | 20.0 | Moderate | 19 | 63.3 | 1 | 5.3 | 18 | 94.7 |
| Severe | 11 | 36.7 | 2 | 18.2 | 9 | 81.8 | |||||
| Appetite, 0-3, 4-5, 6-10 | |||||||||||
| NASM | 19 | 63.3 | 11 | 36.7 | Moderate | 18 | 60.0 | 4 | 22.2 | 14 | 77.8 |
| Severe | 12 | 40.0 | 1 | 8.3 | 11 | 91.7 | |||||
| ATSM | 19 | 67.9 | 9 | 32.1 | Moderate | 19 | 67.9 | 2 | 10.5 | 17 | 89.5 |
| Severe | 9 | 32.1 | 0 | 0 | 9 | 100.00 | |||||
| Constipation, 0-3, 4-6, 7-10 | |||||||||||
| NASM | 9 | 60.0 | 6 | 40.0 | Moderate | 12 | 80.0 | 2 | 16.7 | 10 | 83.3 |
| Severe | 3 | 20.0 | 0 | 0 | 3 | 100.0 | |||||
| ATSM | 22 | 81.5 | 5 | 18.5 | Moderate | 17 | 63.0 | 2 | 11.8 | 15 | 88.2 |
| Severe | 10 | 37.0 | 2 | 20.0 | 8 | 80.0 | |||||
| Cough, 0-2, 3-4, 5-10 | |||||||||||
| NASM | 11 | 64.7 | 6 | 35.3 | Moderate | 8 | 47.1 | 4 | 50.0 | 4 | 50.0 |
| Severe | 9 | 52.9 | 2 | 22.2 | 7 | 77.8 | |||||
| ATSM | 9 | 64.3 | 5 | 35.7 | Moderate | 4 | 28.6 | 1 | 25.0 | 3 | 75.0 |
| Severe | 10 | 71.4 | 0 | 0.00 | 10 | 100.0 | |||||
| Depression, 0-1, 2-3, 4-10 | |||||||||||
| NASM | 15 | 62.5 | 9 | 37.5 | Moderate | — | — | — | |||
| Severe | 24 | 100.0 | 10 | 41.7 | 14 | 58.3 | |||||
| ATSM | 20 | 90.9 | 2 | 9.1 | Moderate | — | — | — | |||
| Severe | 22 | 100.0 | 4 | 18.2 | 18 | 81.8 | |||||
| Diarrhea, 0-3, 4-5, 6-10 | |||||||||||
| NASM | 8 | 72.7 | 3 | 27.3 | Moderate | 5 | 45.5 | 1 | 20.0 | 4 | 80.0 |
| Severe | 6 | 54.5 | 1 | 16.7 | 5 | 83.3 | |||||
| ATSM | 7 | 63.6 | 4 | 36.4 | Moderate | 8 | 72.7 | 0 | 0 | 8 | 100.0 |
| Severe | 3 | 27.3 | 0 | 0 | 3 | 100.0 | |||||
| Dry mouth, 0-4, 5-8, 9-10 | |||||||||||
| NASM | 18 | 62.1 | 11 | 37.9 | Moderate | 27 | 93.1 | 5 | 18.5 | 22 | 81.5 |
| Severe | 2 | 6.9 | 0 | 0 | 2 | 100.0 | |||||
| ATSM | 14 | 66.7 | 7 | 33.3 | Moderate | 17 | 81.0 | 4 | 23.5 | 13 | 76.5 |
| Severe | 4 | 19.0 | 1 | 25.0 | 3 | 75.0 | |||||
| Dyspnea, 0-2, 3-6, 7-10 | |||||||||||
| NASM | 7 | 43.8 | 9 | 56.3 | Moderate | 14 | 87.5 | 9 | 64.3 | 5 | 35.7 |
| Severe | 2 | 12.5 | 0 | 0.00 | 2 | 100.0 | |||||
| ATSM | 11 | 64.7 | 6 | 35.3 | Moderate | 14 | 82.4 | 3 | 21.4 | 11 | 78.6 |
| Severe | 3 | 17.7 | 1 | 33.3 | 2 | 66.7 | |||||
| Fatigue, 0-1, 2-4, 5-10 | |||||||||||
| NASM | 43 | 78.2 | 12 | 21.8 | Moderate | 15 | 27.3 | 11 | 73.3 | 4 | 26.7 |
| Severe | 40 | 72.7 | 17 | 42.5 | 23 | 57.5 | |||||
| ATSM | 39 | 73.6 | 14 | 25.4 | Moderate | 14 | 26.4 | 11 | 78.6 | 3 | 21.4 |
| Severe | 39 | 73.6 | 12 | 30.8 | 27 | 69.2 | |||||
| Vomiting, 0-3, 4-6, 7-10 | |||||||||||
| NASM | 12 | 66.7 | 6 | 33.3 | Moderate | 13 | 72.2 | 2 | 15.4 | 11 | 84.6 |
| Severe | 5 | 27.8 | 0 | 0 | 5 | 100.0 | |||||
| ATSM | 14 | 66.7 | 7 | 33.3 | Moderate | 15 | 71.4 | 4 | 26.7 | 11 | 73.3 |
| Severe | 6 | 28.6 | 0 | 0 | 6 | 100.0 | |||||
| Pain, 0-1, 2-4, 5-10 | |||||||||||
| NASM | 22 | 71.0 | 9 | 29.0 | Moderate | 16 | 51.6 | 5 | 31.3 | 11 | 68.7 |
| Severe | 15 | 48.4 | 5 | 33.3 | 10 | 66.7 | |||||
| ATSM | 13 | 72.2 | 5 | 27.8 | Moderate | 3 | 16.7 | 2 | 66.7 | 1 | 33.3 |
| Severe | 15 | 83.3 | 4 | 26.7 | 11 | 73.3 | |||||
| Peripheral neuropathy, 0-3, 4-7, 8-10 | |||||||||||
| NASM | 8 | 66.7 | 4 | 33.3 | Moderate | 12 | 100.0 | 8 | 66.7 | 4 | 33.3 |
| Severe | 0 | 0 | 0 | 0 | 0 | 0 | |||||
| ATSM | 13 | 56.5 | 10 | 43.5 | Moderate | 19 | 82.6 | 3 | 15.8 | 16 | 84.2 |
| Severe | 4 | 17.4 | 1 | 25.0 | 3 | 75.0 | |||||
| Difficulty remembering, 0-1, 2-4, 5-10 | |||||||||||
| NASM | 23 | 79.3 | 6 | 20.7 | Moderate | 14 | 48.3 | 8 | 57.1 | 6 | 42.9 |
| Severe | 15 | 51.7 | 4 | 26.7 | 11 | 73.3 | |||||
| ATSM | 15 | 88.2 | 2 | 11.8 | Moderate | 6 | 35.3 | 3 | 50.0 | 3 | 50.0 |
| Severe | 11 | 64.7 | 4 | 36.4 | 7 | 63.6 | |||||
| Sleep disturbance, 0-3, 4-6, 7-10 | |||||||||||
| NASM | 28 | 73.7 | 10 | 26.3 | Moderate | 25 | 65.8 | 9 | 36.0 | 16 | 64.0 |
| Severe | 13 | 34.2 | 1 | 7.7 | 12 | 92.3 | |||||
| ATSM | 21 | 70.0 | 9 | 30.0 | Moderate | 17 | 56.7 | 5 | 29.4 | 12 | 70.6 |
| Severe | 13 | 43.3 | 2 | 15.4 | 11 | 84.6 | |||||
| Weakness, 0-2, 3-4, 5-10 | |||||||||||
| NASM | 26 | 74.3 | 9 | 25.7 | Moderate | 15 | 42.9 | 7 | 46.7 | 8 | 53.3 |
| Severe | 20 | 57.1 | 5 | 25.0 | 15 | 75.0 | |||||
| ATSM | 18 | 69.2 | 8 | 30.8 | Moderate | 4 | 15.4 | 1 | 25.0 | 3 | 75.0 |
| Severe | 22 | 84.6 | 8 | 36.4 | 14 | 63.6 | |||||
Abbreviations: NASM, Nurse-Administered Symptom Management; ATSM, Automated Telephone Symptom Management.
*
With ranges for none/mild, moderate, severe.
†
% is for each symptom, of those who ever reached threshold of 4 (or severity ≥ 5 for dry mouth) during intervention.