Table 1.
Patient Characteristics at Baseline
| Characteristic | Overall (N = 297)*
|
Menopausal Status
|
P† | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Premenopausal (n = 93)
|
Perimenopausal (n = 37)
|
Postmenopausal (n = 164)
|
|||||||
| No. | % | No. | % | No. | % | No. | % | ||
| Age, years | < .0001 | ||||||||
| Mean | 52.1 | 43.2 | 49.1 | 57.9 | |||||
| Range | 29-87 | 29-57 | 40-59 | 35-87 | |||||
| BMI, kg/m2 | 28.0 ± 0.4 | 27.2 ± 0.7 | 28.1 ± 1.1 | 28.4 ± 0.5 | .29 | ||||
| Ethnicity | |||||||||
| White | 275 | 92.6 | 87 | 93.8 | 34 | 91.9 | 154 | 93.6 | .70 |
| Other | 19 | 6.5 | 6 | 6.2 | 3 | 8.1 | 10 | 6.4 | |
| Prior chemotherapy | 142 | 47.8‡ | 44 | 46.8 | 19 | 51.4 | 78 | 47.6 | .89 |
| Prior ET | |||||||||
| Yes | 102 | 34.3 | 4 | 4.3 | 8 | 21.6 | 90 | 55.5 | < .001 |
| No | 147 | 49.5 | 72 | 77.7 | 26 | 70.3 | 48 | 29.3 | |
| Unknown | 48 | 16.7 | 17 | 18.1 | 3 | 8.1 | 26 | 15.9 | |
| SSRI/SNRI | |||||||||
| Yes | 55 | 14.1 | 13 | 14.0 | 9 | 24.3 | 33 | 20.1 | .18 |
| No | 230 | 81.8 | 78 | 84 | 24 | 64.9 | 128 | 78.0 | |
| Unknown | 12 | 4 | 2 | 2.2 | 4 | 10.8 | 3 | 1.8 | |
| Hot flash frequency | 12.7 ± 1.1 | 8.6 ± 1.6 | 13.9 ± 2.7 | 15.0 ± 1.7 | .03 | ||||
| Hot flash score§ | 20.9 ± 2.2 | 12.5 ± 2.8 | 22.7 ± 5.9 | 25.3 ± 3.2 | .02 | ||||
Abbreviations: BMI, body mass index; ET, estrogen therapy; SSRI/SNRI, selective serotonin or serotonin-noradrenergic reuptake inhibitor.
*
Menopausal status was unknown in three women who are, therefore, not included in the subgroup comparison.
†
Comparison among different menopausal status stages.
‡
One patient who had prior chemotherapy did not provide information regarding her menopausal status.
§
Hot flash score equals hot flash frequency times hot flash severity.