Table 2.

Hot Flash Score During the First Year of Tamoxifen Treatment

Time, Months	Score by Treatment Group								P*
	Overall		Premenopausal		Perimenopausal		Postmenopausal
	No.	Mean ± SE	No.	Mean ± SE	No.	Mean ± SE	No.	Mean ± SE
Baseline†	286	20.9 ± 2.1	94	13.9 ± 2.9	36	22.7 ± 4.9	156	24.7 ± 3.2	0.02
1‡	250	32.5 ± 3.1	80	30.2 ± 6.3	30	32.0 ± 7.9	139	34.0 ± 3.9	0.58
4§	238	32.5 ± 3.4	77	27.5 ± 5.5	26	52.2 ± 10.7	134	38.9 ± 4.8	0.14
8§	213	37.6 ± 3.8	65	30.0 ± 6.7	23	48.0 ± 9.5	124	39.4 ± 5.1	0.27
12§	212	37.9 ± 4.4	67	36.2 ± 10.3	21	45.9 ± 11.1	123	37.3 ± 4.8	0.90

Abbreviation: SE, standard error.

^*Comparison of premenopausal v postmenopausal patients.

^†All patients who returned their hot flash diaries provided information regarding their menopausal status.

^‡One participant who did not provide information regarding her menopausal status returned hot flash diaries on months 1, 4, 8, and 12.

^§Comparison among different menopausal status stages.