TABLE 1.
RELATIVE ABUNDANCE OF MICRORNAS IN THE EMBRYONIC LUNG: THE 20 MOST ABUNDANT MICRORNA FAMILIES IN E11.5 LUNG
| Family Name | Family Members in Mouse | E11.5 Clones | Relative Abundance (%) |
|---|---|---|---|
| miR-17 | miR-17-5p/106a/106b/18/20a/20b/93 | 175 | 10.5 |
| miR-125 | miR-125a/125b | 91 | 5.5 |
| miR-130 | miR-130a/130b/301a/301b | 70 | 4.2 |
| miR-199 | miR-199a/199b | 64 | 3.8 |
| miR-15 | miR-15a/15b/16 | 58 | 3.5 |
| miR-8 | miR-200a/200b/200c/141/429 | 47 | 2.8 |
| miR-27 | miR-27a/27b | 44 | 2.6 |
| miR-199a* | miR-199a* | 41 | 2.5 |
| miR-25 | miR-25/92 | 40 | 2.4 |
| let-7 | let-7a/b/c/d/e/f/g/i/miR-98 | 38 | 2.3 |
| miR-21 | miR-21 | 38 | 2.3 |
| miR-136 | miR-136 | 32 | 1.9 |
| miR-99 | miR-99a/99b/100 | 22 | 1.3 |
| miR-214 | miR-214 | 20 | 1.2 |
| miR-19 | miR-19a/19b | 20 | 1.2 |
| miR-23 | miR-23a/23b | 19 | 1.1 |
| miR-30 | miR-30a/30b/30c/30d/30e | 18 | 1.1 |
| miR-126-3p | miR-126-3p | 17 | 1.0 |
| miR-351 | miR-351 | 17 | 1.0 |
| miR-26 | miR-26a/26b | 17 | 1.0 |
A total of 1,668 and 1,941 clones was obtained from E11.5 and E17.5 total lung RNA, respectively; 69.1% of E11.5 clones and 89.2% of E17.5 clones are known microRNAs (miRNAs). The definition of miRNA families was derived from http://microrna.sanger.ac.uk.