TABLE 1.
EXPRESSION PROFILING FOR CANDIDATE GENE SELECTION IN VENTILATOR-ASSOCIATED ACUTE LUNG INJURY: IN SILICO APPROACH
| Gene* | Gene Symbol | Fold Change (ventilation vs. control) |
|---|---|---|
| ALI related | ||
| Interleukin 1β | IL-1β | 1.53 |
| Interleukin 6 | IL-6 | 1.84 |
| Tissue factor/thromboplastin | F3 | 1.52 |
| Plasminogen activator inhibitor type 1 | PAI-1 | 1.47 |
| Cyclooxygenase II | COX2 | 1.79 |
| Interleukin 13 | IL-13 | 1.30 |
| Aquaporin 1 | AQP-1 | −1.30 |
| Plasminogen activator, urokinase receptor | PLAUR | 1.47 |
| FGA, fibrinogen alpha; | FGA | 1.30 |
| CCAAT/enhancer-binding protein | C/EBP | 1.40 |
| Interleukin 1 receptor antagonist | CCL2 | 2.00 |
| Adrenomedullin receptor | ADMR | −1.35 |
| VALI candidates | ||
| Chemokine (C-X-C motif) receptor 4 | CXCR4 | 1.62 |
| Gap junction protein, alpha 1 (connexin 43) | GJA-1 | 1.33 |
| Interleukin 1 receptor, type II | IL1R2 | 1.88 |
| Growth arrest DNA damage-inducible, alpha | GADD45α | 1.71 |
| B-cell translocation gene 1 | BTG-1 | 1.38 |
| Trefoil factor 2 (spasmolytic protein 1) | TFF-2 | −1.32 |
Definition of abbreviations: ALI = acute lung injury; VALI = ventilator-associated acute lung injury.
*
Candidate genes achieved more than 1.30-fold change in expression from rat, murine, and canine models and human samples with ALI or VALI compared with controls (P < 0.05).