TABLE 1.
PUBLISHED RESPONSES TO BLVR AND LVRS
| Volume Reduction Therapy | Exercise Capacity (6MWD meters) | Spirometry | Lung Volumes | Overall Response Pattern |
|---|---|---|---|---|
| Emphasys endobronchial valve* | Range of group mean responses across 6 studies (+0 to +152m) | Range of group mean responses 6 studies (−4% to +46%) Meta analysis | Range of group mean responses 6 studies (0% to −11%) | Pattern 1 |
| Meta analysis | FEV1 = 11 ± 26% | Meta analysis | ||
| +37 ± 90 m | FVC = 9 ± 24% | −5 ± 17% | ||
| Biological sealant/remodeling system† | Combined mean response of 2 and 4 site treatments | Combined mean response of 2 and 4 site treatments (n=15 patients) | Range of group mean responses (n=15 patients) | Pattern 1 |
| + 30 ± 34 m | FEV1 = −1 ± 13% | −3 ± 7% | ||
| FVC = 10 ± 14% | ||||
| Bypass tract system | Sufficient published data not currently available | |||
| Unilateral LVRS‡ (includes responses for heterogeneous and homogeneous patients) | Summary 3 month responses from 3 studies | Summary 3 month responses from 3 studies | Summary 3 month responses from 3 studies | Pattern 4 |
| 56 m | FEV1 = +24% | −16% | ||
| FVC = +18% | ||||
| Bilateral LVRS for homogeneous disease§ (includes results from patients with alpha-1 trypsin deficiency) | Summary 3 month responses from 3 studies | Summary 3 month responses from 3 studies | Summary 3 month responses from 3 studies | Pattern 4 |
| 75 m | FEV1 = +35% | −22% | ||
| FVC = +23% | ||||
| Bilateral LVRS for heterogeneous disease‖ | Summary 3-6 month responses from 4 small randomized studies | Summary 3-6 month responses from 4 small randomized studies | Summary 3-6 month responses from 4 small randomized studies | |
| 47 m | FEV1 = +34% | RV = −23% | Type 4 | |
| FVC = +16% | ||||
*
Results summarized from references 18, 20, 21, 29, 30, 31.
†
Results summarized from references 34 and 40.
‡
Results summarized from references 36, 38, 39.
§
Results summarized from references 40, 41, 42.
‖
Results summarized from references 3, 6, 7, 43.