Table 5.

Regions where the effect of emotional content on BOLD response to target stimuli was modulated by tryptophan depletion (i.e. treatment × condition interactions)

Region	Laterality	Stereotaxic coordinates			Cluster size	Z value
Emotional-neutral targets TRP−>TRP+		X	Y	Z
Parietal operculum	L	−48	−34	24	88	4.88a
Ventral putamen	L	−32	−13	3	223†	4.09a
Parahippocampal gyrus	R	32	−39	−11	78	4.02b
Anterior insula/putamen	R	30	8	5	148 †	3.66a
Medial cerebellum	L	−16	−46	−28	27	3.6a
Thalamus	R	16	−23	−2	36	3.55a
Parietal operculum	R	36	−28	14	26	3.49b
Putamen	L	−24	10	5	69	3.46a
Hippocampal formation	L	−24	−29	−7	22	3.46a
Amygdala/ ventral globus pallidus	L	−20	−8	−3	28	3.4a
Emotional-neutral targets TRP+>TRP−
Dorsolateralprefrontal C	R	40	35	31	23	3.86c
Happy-sad targets TRP+>TRP−
Superior temporal G	R	57	−27	3	95	4.22d

Abbreviations: TRP − and TRP + refer to the tryptophan depletion and sham depletion conditions, respectively; other abbreviations and interpretation of stereotaxic coordinates as in Table 3.

^†cluster significant at p<0.05 (corrected in terms of spatial extent)

^aInteraction characterised by increased BOLD response to emotional targets following tryptophan depletion (see Figure 1b)

^bInteraction characterized by an attenuation of deactivation to emotional targets following tryptophan depletion

^cInteraction characterized by increased BOLD response to neutral targets following tryptophan depletion (see Figure 1d)

^dInteraction characterized by greater BOLD response to happy targets than sad targets following sham depletion, with the opposite pattern of response following tryptophan depletion. Italic font denotes that the maximum was contained within an a priori specified region of interest.